selected publications
Zheng, Z., Zhang, C., Zhang, K. 2011. Measurement of ER Stress Response and Inflammation in the Mouse Model of Non-alcoholic Fatty Liver Disease Methods in Enzymology 489: 329-348
Zhang, k.*, Wang, s., Malhotra, j., Hassler, J.R., Back, S.H., Wang, G., Chang, L., Xu, W., Miao, H., Leonardi, R., Chen, E.Y., Jackowski, S., and Kaufman R.J.* 2011. The Unfolded Protein Response Transducer IRE1α Prevents ER Stress-Induced Hepatic Steatosis. EMBO J (In Press)
* Corresponding author
Laing, S., Wang, G., Briazova, T., Zhang, C., Wang, A., Zheng, Z., Gow, A., Chen, A.F., Rajagopalan, S., Chen, L.C., Sun, Q., Zhang, K. 2010. Airborne particulate matter selectively activates endoplasmic reticulum stress response in the lung and liver tissues. Am J Physiol Cell Physiol. 299(4):C736-749.
# Editorial Focus on this article published in AJP: Am J Physiol Cell Physiol. 2010, 299:C727-C728.
Vecchi, C., Montosi, G., Zhang, K., Lamberti, I., Duncan, S.A., Kaufman, R.J., Pietrangelo, A. 2009. ER Stress Controls Iron Metabolism Through Induction of Hepcidin. Science325: 877-880.
Malhotra, J.D., Miao, H., Zhang, K., Wolfson, A., Pennathur, S., Pipe, S.W., Kaufman, R.J. 2008. Antioxidants reduce endoplasmic reticulum stress and improve protein secretion. Proc Natl Acad Sci USA 105 (47):18525-18530.
Luebke-Wheeler J, Zhang K, Battle M, Si-Tayeb K, Garrison W, Chhinder S, Li J, Kaufman RJ, Duncan SA. 2008. Hepatocyte nuclear factor 4α is implicated in endoplasmic reticulum stress-induced acute phase response by regulating expression of CREB-H. Hepatology 48(4):1242-1250
Kurachi, S., Huo, J., Ameri, A., Zhang, K., Yoshizawa, A., Kurachi, K. 2009. An Age Related Homeostasis Mechanism is Essential for Spontaneous Amelioration of Hemophilia B Leyden. Proc Natl Acad Sci USA 106 (19):7921-7926.
Zhang, K., Kaufman, R.J. 2008. Identification and Characterization of Endoplasmic Reticulum Stress-induced Apoptosis in vivo. Methods Enzymol. 442:395-419.
Zhang, K., Kaufman, R.J. 2008. From endoplasmic-reticulum stress to the inflammatory response. Nature 454(7203):455-462.
Zhang, K., Shen, X., Wu, J., Sakaki, K., Saunders, T., Rutkowski, D.T., Back, S.H., Kaufman, R.J. 2006. Endoplasmic Reticulum Stress Activates Cleavage of CREBH to Induce a Systemic Inflammatory Response. Cell 124: 587-599.
Zhang, K., Wong, H.N., Song, B., Miller, C.N., Scheuner, D., Kaufman, R.J. 2005. The unfolded protein response sensor IRE1α is required at 2 distinct steps in B cell lymphopoiesis. J. Clin. Invest. 115 (3): 268-281.
Hsu, L.H., Park, J.M., Zhang, K., Luo, J.L., Maeda, S., Kaufman, R.J., Eckmann, L., Guiney, D.G., Karin, M. 2004. The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4. Nature428 (6980): 341-345.
Zhang, K., Kurachi, S., Kurachi, K. 2003. Limitation in use of heterologous reporter genes for gene promoter analysis: silencer activity associated with the chloramphenicol acetyltransferase reporter gene. J. Biol. Chem.278 (7): 4826-4830
Krebsbach, P., Zhang, K., Malik, A., Kurachi, K. 2003. Bone marrow stromal cells as a Genetic platform for systemic delivery of therapeutic proteins in vivo: human factor IX model. J. Gene Med. 5(1): 11-7
Zhang, K., Kurachi, S., Kurachi, K. 2002. Genetic mechanisms of age regulation of protein C and blood coagulation. J. Biol. Chem. 277 (6): 4532-4540