? Zhang Laboratory

Selected Publications

Zhang, K.#, Kim, H., Fu, Z., Qiu, Y., Yang, Z., Wang, J., Zhang, D., Tong, X., Yin, L., Li, J., Wu, J., Qi, N.R., Houten, S.M., Zhang, R.# 2017. Deficiency of the mitochondrial NAD kinase causes stress-induced non-alcoholic steatohepatitis. Gastroenterology (in press) [# corresponding authors]

Kim H, Zheng Z, Walker PD, Kapatos G, Zhang K. CREBH Maintains Circadian Glucose Homeostasis by Regulating Hepatic Glycogenolysis and Gluconeogenesis. Mol Cell Biol. 2017 Jun 29;37(14). [Cover Story]

Wang JM, Qiu Y, Yang ZQ, Li L, Zhang K. Inositol-Requiring Enzyme 1 Facilitates Diabetic Wound Healing Through Modulating MicroRNAs. Diabetes 2017 Jan;66(1):177-192

Zheng Z, Kim H, Qiu Y, Chen X, Mendez R, Dandekar A, Zhang X, Zhang C, Liu AC, Yin L, Lin JD, Walker PD, Kapatos G, Zhang K. CREBH Couples Circadian Clock With Hepatic Lipid Metabolism. Diabetes 2016 Nov;65(11):3369-3383

Zheng Z, Zhang X, Wang J, Dandekar A, Kim H, Qiu Y, Xu X, Cui Y, Wang A, Chen LC, Rajagopalan S, Sun Q, Zhang K. Exposure to fine airborne particulate matters induces hepatic fibrosis in murine models. J Hepatol. 2015 Dec;63(6):1397-404

Kim H, Mendez R, Chen X, Fang D, Zhang K. Lysine Acetylation of CREBH Regulates Fasting-Induced Hepatic Lipid Metabolism. Mol Cell Biol. 2015 Dec;35(24):4121-34

Zhang X, Cai J, Zheng Z, Polin L, Lin Z, Dandekar A, Li L, Sun F, Finley RL Jr, Fang D, Yang ZQ, Zhang K. A novel ER-microtubule-binding protein, ERLIN2, stabilizes Cyclin B1 and regulates cell cycle progression. Cell Discovery 2015 Sep 8;1:15024

Su, Q., Baker, C., Christian, P., Naples, M., Tong, X., Zhang, K., Santha, M., Adeli, K. 2014. Hepatic mitochondrial and ER stress induced by defective PPARa signaling in the pathogenesis of hepatic steatosis. Am J Physiol. (Endocrinol Metab) 306: E1264-1273

Kim, H., Mendez, R., Zheng, Z., Chang, L., Cai, J., Zhang, R., and Zhang, K. 2014. Liver-enriched Transcription Factor CREBH Interacts with Peroxisome Proliferator-activated Receptor a to Regulate Metabolic Hormone FGF21. Endocrinology 155: 769-782.

Nevell, L., Zhang, K., Aiello, A., Koenen, K., Galea, S., Soliven, R., Zhang, C., Wildman, D., Uddin, M. 2014. Elevated systemic expression of ER stress related genes is associated with stress-related mental disorders in the Detroit Neighborhood Health Study. Psychoneuroendocrinology 43: 62-70.

Zheng, Z., Zhang, C., Yan, J., Ruan, Y., Zhao, X., San, X., Mao, Y., Sun, Q.#, Zhang, K.#, Fan, Z.# 2013. Diabetes Mellitus is associated with Hepatocellular Carcinoma: a Retrospective Case-control Study in Hepatitis Endemic Area. Plos One 8(12): e84776. (# corresponding author).

Kemp, K.L., Li, Z., Zhao, F., Gao, B., Song, J., Zhang, K., Fang, D. 2013. The serine-threonine kinase Inositol-requiring enzyme 1 a (IRE1a) promotes IL-4 production in T helper cells. J. Biol. Chem. 288: 33272-33282.

Qiu, Q., Zheng, Z., Chang, L., Zhao, Y.S., Tan, C., Dandekar, A., Zhang, Z., Lin, Z., Gui, M., Li, X., Zhang, T., Kong, Q., Li, H., Chen, S., Chen, A., Kaufman, R.J., Yang, W.L., Lin, H.K., Zhang, D., Perlman, H., Thorp, E., Zhang, K.#, Fang, D#. 2013. Toll-like receptor-mediated IRE1a activation as a therapeutic target for inflammatory arthritis. EMBO J. 32(18):2477-2490. (# corresponding author).

Mendez, R., Zheng, Z., Fan, Z., Rajagopalan, S., Sun, Q., Zhang, K. 2013 Exposure to fine airborne particulate matter induces macrophage infiltration, unfolded protein response, and lipid deposition in white adipose tissue.Am J Transl Res5(2):224-34

Zheng, Z., Xu, X., Zhang, X., Wang, A., Zhang, C., Huttemann, M., Grossman, L.I., Chen, L.C., Rajagopalan, S., Sun, Q., Zhang, K. 2013. Exposure to ambient particulate matter induces a NASH-like phenotype and impairs hepatic glucose metabolism in an animal model.J Hepatol 58(1): 148-54

Lee, J.S., Zheng, Z., Mendez, R., Ha, S.W., Xie, Y., Zhang, K. 2012. Pharmacologic ER stress induces non-alcoholic steatohepatitis in an animal model. Toxicol Lett 211(1):29-38

Zhang, C., Wand, G,. Zheng, Z., Maddipati, K.R., Zhang, X., Dyson, G., Williams, P., Duncan, S.A., Kaufman, R.J., Zhang, K. 2012. Endoplasmic reticulum-tethered transcription factor cAMP responsive element-binding protein, hepatocyte specific, regulates hepatic lipogenesis, fatty acid oxidation, and lipolysis upon metabolic stress in mice. Hepatology 55(4):1070-82

Zhang, X., Zhang, K. 2012. Endoplasmic reticulum stress-associated lipid droplet formation and type II diabetes. Biochem Res Int 2012:247275

Wang, G., Liu, G., Wang, X., Sethi, S., Ali-Fehmi, R., Abrams, J., Zheng, Z., Zhang, K., Ethier, S., Yang, Z.Q. 2012. ERLIN2 promotes breast cancer cell survival by modulating endoplasmic reticulum stress pathways. BMC Cancer 12: 225

Lee, J.S., Mendez, R., Heng, H.H., Yang, Z.Q., Zhang, K. 2012. Pharmacological ER stress promotes hepatic lipogenesis and lipid droplet formation. Am J Transl Res 4(1): 102-13

Zheng, Z., Zhang, C., Zhang, K. 2011. Measurement of ER Stress Response and Inflammation in the Mouse Model of Non-alcoholic Fatty Liver Disease. Methods in Enzymology 489: 329-348

Zhang, K.*, Wang, S., Malhotra, J., Hassler, J.R., Back, S.H., Wang, G., Chang, L., Xu, W., Miao, H., Leonardi, R., Chen, E.Y., Jackowski, S., and Kaufman R.J.* 2011. The Unfolded Protein Response Transducer IRE1a Prevents ER Stress-Induced Hepatic Steatosis. EMBO J 30(7):1357-75
* Corresponding author

Zheng, Z., Zhang, C., Zhang, K. 2010. Role of unfolded protein response in lipogenesis World J Hepatol 2(6): 203-7

Laing, S., Wang, G., Briazova, T., Zhang, C., Wang, A., Zheng, Z., Gow, A., Chen, A.F., Rajagopalan, S., Chen, L.C., Sun, Q., Zhang, K. 2010. Airborne particulate matter selectively activates endoplasmic reticulum stress response in the lung and liver tissues. Am J Physiol Cell Physiol. 299(4):C736-749.
#  Editorial Focus on this article published in AJP: Am J Physiol Cell Physiol. 2010, 299:C727-C728.

Vecchi, C., Montosi, G., Zhang, K., Lamberti, I., Duncan, S.A., Kaufman, R.J., Pietrangelo, A. 2009. ER Stress Controls Iron Metabolism Through Induction of Hepcidin. Science325: 877-880.

Malhotra, J.D., Miao, H., Zhang, K., Wolfson, A., Pennathur, S., Pipe, S.W., Kaufman, R.J. 2008. Antioxidants reduce endoplasmic reticulum stress and improve protein secretion. Proc Natl Acad Sci USA 105 (47):18525-18530.

Luebke-Wheeler J, Zhang K, Battle M, Si-Tayeb K, Garrison W, Chhinder S, Li J, Kaufman RJ, Duncan SA. 2008. Hepatocyte nuclear factor 4a is implicated in endoplasmic reticulum stress-induced acute phase response by regulating expression of CREB-H. Hepatology 48(4):1242-1250

Kurachi, S., Huo, J., Ameri, A., Zhang, K., Yoshizawa, A., Kurachi, K. 2009. An Age Related Homeostasis Mechanism is Essential for Spontaneous Amelioration of Hemophilia B Leyden. Proc Natl Acad Sci USA 106 (19):7921-7926.

Zhang, K., Kaufman, R.J. 2008. Identification and Characterization of Endoplasmic Reticulum Stress-induced Apoptosis in vivo. Methods Enzymol. 442:395-419.

Zhang, K., Kaufman, R.J. 2008. From endoplasmic-reticulum stress to the inflammatory response. Nature 454(7203):455-462.

Zhang, K., Shen, X., Wu, J., Sakaki, K., Saunders, T., Rutkowski, D.T., Back, S.H., Kaufman, R.J. 2006. Endoplasmic Reticulum Stress Activates Cleavage of CREBH to Induce a Systemic Inflammatory Response. Cell 124: 587-599.

Zhang, K., Wong, H.N., Song, B., Miller, C.N., Scheuner, D., Kaufman, R.J. 2005. The unfolded protein response sensor IRE1a is required at 2 distinct steps in B cell lymphopoiesis. J. Clin. Invest. 115 (3): 268-281.

Hsu, L.H., Park, J.M., Zhang, K., Luo, J.L., Maeda, S., Kaufman, R.J., Eckmann, L., Guiney, D.G., Karin, M. 2004. The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4. Nature428 (6980): 341-345.

Zhang, K., Kurachi, S., Kurachi, K. 2003. Limitation in use of heterologous reporter genes for gene promoter analysis: silencer activity associated with the chloramphenicol acetyltransferase reporter gene. J. Biol. Chem.278 (7): 4826-4830

Krebsbach, P., Zhang, K., Malik, A., Kurachi, K. 2003. Bone marrow stromal cells as a Genetic platform for systemic delivery of therapeutic proteins in vivo: human factor IX model. J. Gene Med. 5(1): 11-7

Zhang, K., Kurachi, S., Kurachi, K. 2002. Genetic mechanisms of age regulation of protein C and blood coagulation. J. Biol. Chem. 277 (6): 4532-4540